منابع مشابه
Sepsis and therapeutic hypercapnia: sailing too close to the wind?
ALMOST a decade ago, the landmark study of low tidal volume ventilation (6 vs. 12 ml/kg ideal body weight) in the acute respiratory distress syndrome (ARDS) showed that a strategy leading in some cases to carbon dioxide retention (permissive hypercapnia) reduced mortality by a remarkable 25%. Lung protective ventilation is now the standard of care for acute lung injury and ARDS. Lack of obvious...
متن کاملHypercapnia and acidosis in sepsis: a double-edged sword?
Acute respiratory distress syndrome is a devastating disease that causes substantial morbidity and mortality. Mechanical ventilation can worsen lung injury, whereas ventilatory strategies that reduce lung stretch, resulting in a "permissive" hypercapnic acidosis (HCA), improve outcome. HCA directly reduces nonsepsis-induced lung injury in preclinical models and, therefore, has therapeutic poten...
متن کاملTargeted therapeutic mild hypercapnia after cardiac arrest
Cardiac arrest (CA) causes ischaemic brain injury and persistent cerebral hypoperfusion and cerebral hypoxia during the early post-resuscitation period. PaCO2 is the major physiological regulator of cerebral blood flow, is a modifiable component of care and mild hypercapnia may lead to improved neurological outcomes for resuscitated CA survivors. In order to evaluate the potential therapeutic r...
متن کاملSepsis: Diagnostic and Therapeutic Challenges
1Department of Anaesthesiology and Intensive Therapy, Faculty of Medicine, University of Szeged, 6 Semmelweis St., Szeged 6725, Hungary 24th Department of Internal Medicine, Attikon University Hospital, 1 Rimini Str., 12462 Athens, Greece 3Sections of Critical Care Medicine and Infectious Diseases, Medical Microbiology and Pharmacology, University of Manitoba, Winnipeg, MB, Canada 4Department o...
متن کاملEffects of therapeutic hypercapnia on mesenteric ischemia-reperfusion injury.
Hypercapnic acidosis protects against direct lung injury in in vivo and ex vivo models, however, lung injury/acute respiratory distress syndrome commonly occurs after a nonpulmonary etiology. We investigated whether therapeutic hypercapnia (TH)-deliberate elevation of carbon dioxide (CO2) tension-would protect against lung injury after splanchnic ischemia-reperfusion injury in an in vivo model....
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ژورنال
عنوان ژورنال: Anesthesiology
سال: 2010
ISSN: 0003-3022
DOI: 10.1097/aln.0b013e3181ca33be